منابع مشابه
Heterotrimeric G proteins in C. elegans.
Heterotrimeric G proteins, composed of alpha, beta, and gamma subunits, are able to transduce signals from membrane receptors to a wide variety of intracellular effectors. In this role, G proteins effectively function as dimers since the signal is communicated either by the G alpha subunit or the stable G betagamma complex. When inactive, G alpha-GDP associates with G betagamma and the cytoplas...
متن کاملAccessory proteins for heterotrimeric G-proteins in the kidney
Heterotrimeric G-proteins play a fundamentally important role in regulating signal transduction pathways in the kidney. Accessory proteins are being identified as direct binding partners for heterotrimeric G-protein α or βγ subunits to promote more diverse mechanisms by which G-protein signaling is controlled. In some instances, accessory proteins can modulate the signaling magnitude, localizat...
متن کاملPresynaptic signaling by heterotrimeric G-proteins.
G-proteins (guanine nucleotide-binding proteins) are membrane-attached proteins composed of three subunits, alpha, beta, and gamma. They transduce signals from G-protein coupled receptors (GPCRs) to target effector proteins. The agonistactivated receptor induces a conformational change in the G-protein trimer so that the alpha-subunit binds GTP in exchange for GDP and alpha-GTP, and betagamma-s...
متن کامل[Importance of heterotrimeric G proteins in prostate cancer molecular biology].
OBJECTIVE To deep in the knowledge of the involvement of G-protein alphas and alphai subunits in human prostate cancer. METHODS Prostate tissue from 9 patients undergoing radical prostatectomy for prostate cancer and 5 controls undergoing cystoprostatectomy for bladder carcinoma. G-protein alphas and alphai subunits were studied for expression (mRNA by RT-PCR and protein by Western-blot), fun...
متن کاملNovel somatic mutations in heterotrimeric G proteins in melanoma.
Heterotrimeric guanine nucleotide-binding proteins (G proteins) mediate signals between G-protein coupled receptors and their downstream pathways, and have been shown to be mutated in cancer. In particular, GNAQ was found to be frequently mutated in blue nevi of the skin and uveal melanoma, acting as an oncogene in its mutated form. To further examine the role of heterotrimeric G proteins in ma...
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ژورنال
عنوان ژورنال: Plant Signaling & Behavior
سال: 2014
ISSN: 1559-2324
DOI: 10.4161/psb.28457